Results 141 to 150 of about 4,521,941 (297)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Exploring data reduction strategies in the analysis of continuous pressure imaging technology. [PDF]

BMC Med Res Methodol, 2023
Peng M, Southern DA, Ocampo W, Kaufman J, Hogan DB, Conly J, Baylis BW, Stelfox HT, Ho C, Ghali WA.   +9 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Data reduction for X-ray serial crystallography using machine learning. [PDF]

J Appl Crystallogr, 2023
Rahmani V, Nawaz S, Pennicard D, Setty SPR, Graafsma H.   +4 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Effect of Data Reduction Techniques on Daily Moderate to Vigorous Physical Activity Collected with ActiGraph^® in People with COPD. [PDF]

J Clin Med, 2023
Rebelo P, Antão J, Brooks D, Marques A.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A feasibility analysis of image approximation with image quality assessments

IET Image Processing
With technological developments, the resolution of the display systems is increasing, causing image data to increase. Several technologies are aiding in optimizing these data during transmission and storage while maintaining quality.
Md. Abdur Rahman, Aminul Huq, Salma Sultana Tunny, Maruf Hossain Anik, Mst Tasnim Pervin, Md. Rashidul Islam   +5 more
doaj   +1 more source

Model-based evaluation of spatiotemporal data reduction methods with unknown ground truth through optimal visualization and interpretability metrics. [PDF]

Brief Bioinform, 2023
Atitey K, Motsinger-Reif AA, Anchang B.
europepmc   +1 more source

Subset selection in dimension reduction methods [PDF]

Dimension reduction methods play an important role in multivariate statistical analysis, in particular with high-dimensional data. Linear methods can be seen as a linear mapping from the original feature space to a dimension reduction subspace.
Luca Scrucca
core