Results 91 to 100 of about 1,298,901 (260)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Improved contrastive learning model via identification of false-negatives in self-supervised learning

ETRI Journal
Self-supervised learning is a method that learns the data representation through unlabeled data. It is efficient because it learns from large-scale unla-beled data and through continuous research, performance comparable to supervised learning has been ...
Joonsun Auhn, Changsik Cho, Seon-tae Kim
doaj   +1 more source

Yet Another Compact Time Series Data Representation Using CBOR Templates (YACTS). [PDF]

Sensors (Basel), 2023
Molina Araque S, Martinez I, Papadopoulos GZ, Montavont N, Toutain L.   +4 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Variable body and tissue weight reporting in preclinical cachexia literature may alter study outcomes and interpretation

Disease Models & Mechanisms, 2023
Anna G. Beaudry, Michelle L. Law
doaj   +1 more source

Condensed Representations for Data Mining [PDF]

, 2005
Condensed representations have been proposed in Mannila and Toivonen (1996) as a useful concept for the optimization of typical data-mining tasks. It appears as a key concept within the inductive database framework (Boulicaut et al., 1999; de Raedt, 2002; Imielinski & Mannila, 1996), and this article introduces this research domain, its ...
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The performance of BERT as data representation of text clustering. [PDF]

J Big Data, 2022
Subakti A, Murfi H, Hariadi N.
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Log-based sparse nonnegative matrix factorization for data representation. [PDF]

Knowl Based Syst, 2022
Peng C, Zhang Y, Chen Y, Kang Z, Chen C, Cheng Q.   +5 more
europepmc   +1 more source