Results 111 to 120 of about 958,621 (305)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

The Cost of Grade Retention [PDF]

open access: yes
This paper uses administrative longitudinal micro data on the universe of Junior High school students in Uruguay to measure the effect of grade failure on students' subsequent school outcomes.
Marco Manacorda
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Data-Driven Retention Marketing Development Strategy in Telecom Enterprise

open access: yesDianxin kexue, 2015
As the new market shrink,some new product market become even to zero,the marketing strategy goal transfer from acquisition to customer retention in the telecom enterprise.Because of the gap between the retention marketing goal and the marketing reality ...
Chenxi Qi, Yiming Yu
doaj   +2 more sources

Transparency, Recuitment and Retention in the Public Sector [PDF]

open access: yes
Although performance measurement systems are likely to have significant recruitment and retention consequences these have received much less attention that the individual incentive effects. This paper explores these recruitment and retention consequences
Clare Leaver, Gian Luigi Albano
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Data Retention

open access: yes
The recent judgements of the CJEU on data retention should not be regarded as an authoritarian move towards a less fundamental rights-sensible position of the Court. Rather, the case law adapts the ever more complex development of the constitutional security law, which was originally dominated by the Member States.
openaire   +2 more sources

DATA RETENTION: THE ENIGMATIC RELATIONSHIP BETWEEN SECURITY NEEDS AND PROTECTION OF FUNDAMENTAL RIGHTS

open access: yes
reservedIl presente elaborato si pone l’obiettivo di analizzare la disciplina della data retention, in particolar modo il suo sviluppo normativo e le problematiche ad essa legate.
BORTOLAMI, ELENA
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Factors associated with acquisition and retention of costumers in supply chain services

open access: yes, 2016
The thesis consists of two parts. The first part refers to the literature review of the terms supply chain management and services, costumer acquisition and retention. Second part concerns the survey that has been conducted, the methodology that has been
Γεωργιάδου, Ιφιγένεια   +1 more
core  

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