Results 131 to 140 of about 26,480,428 (300)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

USDA Table of Nutrient Retention Factors, Release 6 (2007)

open access: yes, 2017
Release 6, of this data set, replaces the previous release, Release 5, issued in 2003. The data set contains the factors for calculating retention of 26 vitamins, minerals and alcohol during food preparation.
Nutrient Data Lab (17478261)
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Data Retention – The Belgian Approach

open access: yesMasaryk University Journal of Law and Technology, 2012
Security, privacy and fundamental rights must be realized together and not at the cost of one another. That is the challenge.
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Data Mining to Identify Factors Associated with University Student Retention

open access: yesInformatics
Student retention has become a major challenge for higher education institutions due to the influence that academic, socioeconomic, family, and motivational factors exert on students’ academic continuity.
Yuri Reina Marín   +6 more
doaj   +1 more source

Factors associated with acquisition and retention of costumers in supply chain services

open access: yes, 2016
The thesis consists of two parts. The first part refers to the literature review of the terms supply chain management and services, costumer acquisition and retention. Second part concerns the survey that has been conducted, the methodology that has been
Γεωργιάδου, Ιφιγένεια   +1 more
core  

The effectiveness of grade retention as an intervention strategy for academic failure [PDF]

open access: yes, 2001
Plan BOver the past decade there has been public and political pressure to improve the quality of education. Schools are being encouraged to adopt grade retention policies to help children who are falling behind academically.
Viland, Kelly Rochelle
core  

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