Results 81 to 90 of about 2,154,085 (300)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Prediction of water retention of soils from the humid tropics by the nonparametric k-nearest neighbor approach [PDF]

, 2013
Nonparametric approaches such as the k-nearest neighbor (k-NN) approach are considered attractive for pedotransfer modeling in hydrology; however, they have not been applied to predict water retention of highly weathered soils in the humid tropics ...
Attila Nemes, Babalola, Bannayan, Berg, Botula, Bouma, Bouma, Braudeau, Bronick, Brooks, Buishand, Cornelis, Cornelis, Dam, Dasarathy, Deng, Elshorbagy, Elshorbagy, Eric Van Ranst, Finke, Genuchten, Gharahi Ghehi, Givi, Guber, Gupta, Haghverdi, Hastie, Haykin, Hecht-Nielsen, Hodnett, Hopmans, IUSS Working Group WRB, Jagtap, Köhn, Lal, Loosvelt, Medina, Minasny, Moeys, Mualem, Mucherino, Nemes, Nemes, Nemes, Nemes, Nemes, Nemes, Noble, Ottoni, Pachepsky, Pachepsky, Parasuraman, Parasuraman, Patil, Paul Mafuka, Perkins, Pidgeon, Puckett, Rajkai, Rawls, Reichardt, Reichert, Schaap, Schaap, Schwartz, Sharma, Soil Survey Staff, Soil Survey Staff, Tempel, Tomasella, Tomasella, Tranter, Twarakavi, Van Ranst, Vapnik, Vapnik, Vereecken, Vereecken, Vereecken, Weynants, Williams, Wim M. Cornelis, Wösten, Yves-Dady Botula, Zacharias   +84 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

The selection, appraisal, and retention of social science data

Data Science Journal, 2006
The number of data collections produced in the social sciences prohibits the archiving of every scientific study. It is therefore necessary to make decisions regarding what can be preserved and why it should be preserved. This paper reviews the processes
M Gutmann, K Schürer, D Donakowski, Hilary Beedham   +3 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Unravelling the Data Retention Mechanisms under Thermal Stress on 2D Memristors. [PDF]

ACS Omega, 2023
Aldana S, Zhang H.
europepmc   +1 more source

Defining retention and attrition in pre-antiretroviral HIV care: proposals based on experience in Africa [PDF]

, 2012
This repository item contains a single issue of the Health and Development Discussion Papers, an informal working paper series that began publishing in 2002 by the Boston University Center for Global Health and Development.
Fox, Matthew, Larson, Bruce, Rosen, Sydney   +2 more
core   +2 more sources