Results 91 to 100 of about 728,120 (296)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

A Virtual Infrastructure Model Based on Data Reuse to Support Intelligent Transportation System Applications

IEEE Access
Intelligent Transportation Systems (ITS) have significantly improved transportation quality by using applications capable of monitoring, managing, and improving the transportation system.
Christian Miranda, Antonio Santos da Silva, Joao Paulo Javidi da Costa, Giovanni Almeida Santos, Daniel Alves da Silva, Edison Pignaton de Freitas, Alexey Vinel   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Use It or Lose It: Facilitating the Use of Interactive Data Apps in Psychological Research Data Sharing

Europe's Journal of Psychology
The value of open research data (ORD), a key feature of open science, lies in their reuse. However, the mere online availability of ORD does not guarantee their reuse by other researchers.
Franziska Usée, Christiane A. Melzig, Dirk Ostwald   +2 more
doaj   +1 more source

Refactoring intermediately executed code to reduce cache capacity misses [PDF]

, 2008
The growing memory wall requires that more attention is given to the data cache behavior of programs. In this paper, attention is given to the capacity misses i.e.
Beyls, Kristof, D'Hollander, Erik
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Obstacles to Dataset Citation Using Bibliographic Management Software

Data Science Journal
Governmental, funder, and scholarly publisher mandates for FAIR and open data are pushing researchers to archive data with persistent identifiers in repositories and link datasets in journal articles.
Kristina Vrouwenvelder, Natalie H. Raia, Andrea K. Thomer   +2 more
doaj   +1 more source

Is the survival of patients treated with ipilimumab affected by antibiotics? An analysis of 1585 patients from the French National hospital discharge summary database (PMSI)

OncoImmunology, 2020
Background: The gut microbiota has a key role in the regulation of the immune system. Disruption of the gut microbiota’s composition by antibiotics might significantly affect the efficacy of immune checkpoint inhibitors.
Pierre-Yves Cren, Nicolas Bertrand, Marie-Cécile Le Deley, Michaël Génin, Laurent Mortier, Pascal Odou, Nicolas Penel, Emmanuel Chazard   +7 more
doaj   +1 more source