Results 51 to 60 of about 94,520 (261)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Challenges of reusing marine image-based data for fish and benthic habitat Essential Variables: insights from data producers

Frontiers in Marine Science
Understanding the status and trends of Essential Ocean Variables (EOV) and Essential Biodiversity Variables (EBV) is crucial for informing policy-makers and the public about sustainable management of marine biodiversity.
Dominique Pelletier, Jacquomo Monk, Franziska Althaus, Catherine Borremans, Melissa Hanafi-Portier, Ben Scoulding, Karine Olu, Candice Untiedt, Chris Jackett, Neville Barrett, Pascal Laffargue, Sandrine Vaz, Elizabeth Hasan, Elizabeth Hasan, Alan Williams   +14 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Envisioning a data reuse registry

Nature Precedings, 2008
AbstractRepurposing research data holds many benefits for the advancement of biomedicine, yet is very difficult to measure and evaluate. We propose a data reuse registry to maintain links between primary research datasets and studies that reuse this data.
Heather Piwowar, Wendy Chapman
openaire   +2 more sources

The Maritime Record in Scotland from Recording to Presentation

Internet Archaeology
With approximately 18,743 km of coastline along the high-water line, 462,315 km² of sea and over 900 islands, Scotland has a rich and diverse marine heritage. The maritime record for Scotland forms part of the National Record of the Historic Environment (
Peter McKeague
doaj   +1 more source

Social science research data curation

Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2017
Data curation is attracting a growing interest in the library and information science community. The main purpose of data curation is to support data reuse.
Guangyuan Sun, Christopher S.G Khoo
doaj   +1 more source

Data Reuse: comparing the principles

, 2022
Government and commercial organisations have accrued vast amounts of data over years of investment. This data is worth billions of pounds but is not being reused. The ability to reuse data could deliver better value from the initial investment that has been made by allowing an organisation to use their resources more efficiently potentially saving time
Wood, Zena, Hart, Glen
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Lessons learned from the development of a national registry on dementia care and support based on linked national health and administrative data

Learning Health Systems
Introduction This paper provides insight into the development of the Dutch Dementia Care and Support Registry and the lessons that can be learned from it.
Iris van derHeide, Anneke L. Francke, Carola Döpp, Marianne Heins, Hein P. J. vanHout, Robert A. Verheij, Karlijn J. Joling   +6 more
doaj   +1 more source

Cross-border eServices for public administration driven by Once-Only Principle

Revista Română de Informatică și Automatică, 2020
Nowadays implementing cross-border electronic public services is a top priority for public administrations across EU for accelerating economic development.
Carmen-Elena CÎRNU, Carmen-Ionela ROTUNĂ   +1 more
doaj   +1 more source