Results 141 to 150 of about 4,603,530 (263)

The virtual indigenous data science academy: development of a summer program in data science for tribal college students. [PDF]

Front Public Health
Smith CB, Nadeau M, Adamsen C, Oancea SC, Voels B, Salentiny A, Plume LM, Herbert M, Guinn M, Best LG, Biggane E.   +10 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Connecting data science and translational simulation. [PDF]

Adv Simul (Lond)
Brazil V.
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Empowering precollege data science education with an innovative learning portal. [PDF]

Discov Educ
Shalmani MA, Berg C, Carvan MJ, Hesselbach RA, Petering D, Schiebenes K, Shukla R, Tomasiewicz HG, Weber DN, Luo J.   +9 more
europepmc   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Unleashing potential: assessing Africa's readiness for the data science revolution to impact health. [PDF]

Nat Commun
Panji S, Ras V, Gichoya J, Julius R, Maslamoney S, Motshegwa T, Sharaf A, Skelton M, Tunga M, Mulder N.   +9 more
europepmc   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Data science without borders: bridging the divide in data science capacity across African health institutions. [PDF]

Front Public Health
Kiragga AN, Iddi S, Walekhwa AW, Barasa M, Cygu S, Odhiambo R, Gningue M, Mboup A, Onana A, Adnew B, Alemu Ashuro A, Hudson S, Greenfield J, Todd J, Bhattacharjee T, Sharan M, Sonabend R, Kadengye D, Mbatchou BH, Abdissa A, Sarr M, Nabende JN, Bamutura M, Tamurat B, Dereje N, Temfack E.   +25 more
europepmc   +1 more source