Results 171 to 180 of about 13,729,805 (320)

Beyond the dataset: integrating public voices in data science. [PDF]

open access: yesRes Involv Engagem
Rubio AP   +17 more
europepmc   +1 more source

Data Sciences

open access: yes, 2017
Le recours aux entrepôts de données permet un gain considérable de temps consacrés à l'élaborationde requêtes pour la recherche d'éléments pertinents de prises de décisions. Ainsi l'objectif de cette thèseest de proposer dans un premier temps un modèle dimensionnel adapté au processus de résiliencesociale, de l’évaluation du niveau de vulnérabilité d ...
Par, Présentée   +2 more
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Harnessing data science for health discovery and innovation in Africa (DS-I Africa). [PDF]

open access: yesCommun Med (Lond)
Xiong C   +15 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

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