Results 81 to 90 of about 1,831,151 (266)

Stepping up to the moment: collaborating on a data management and sharing workshop series

Journal of the Medical Library Association
Background: Many researchers benefit from training and assistance with their data management practices. The release of the Office of Science and Technology Policy’s Nelson Memo and the National Institutes of Health’s new Data Management and Sharing ...
Sara Samuel, Yulia Sevryugina, Mark MacEachern, Kate Saylor, Rachel Woodbrook   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The Reality of High Performing Deep Learning Models: A Case Study on Document Image Classification

IEEE Access
Deep neural networks have demonstrated exceptional performance breakthroughs in the field of document image classification; yet, there has been limited research in the field that delves into the explainability of these models. In this paper, we present a
Saifullah, Stefan Agne, Andreas Dengel, Sheraz Ahmed   +3 more
doaj   +1 more source

Establishing a data service: The Numeric GeoSpatial Data Service Proposal

, 2005
Creating a new service within an academic library can be an arduous process even for a seasoned data librarian. For this new librarian, with data services part of the job description and a renowned public opinion center located on campus, investigating, designing, and creating the new service required more than an investigation and reporting of the ...
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Good Omens: New Services, Accurate Research Data

Journal of eScience Librarianship
Research data management and data curation need strong relationships with colleagues, collaborators, and researchers. Because change comes fast, assessment of current services and practices are important so that new paths and initiatives can be developed.
Regina Raboin
doaj   +2 more sources

CoreTrustSeal

Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2018
Open data and data management policies that call for the long-term storage and accessibility of data are becoming more and more commonplace in the research community.
Ingrid Dillo, Lisa de Leeuw
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source