Results 101 to 110 of about 384,420 (258)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Hubungan Antara Volume Prostat dan IPSS Score pada Pasien BPH di Rumah Sakit Siti Khodijah Muhammadiyah Cabang Sepanjang

Jurnal Kesehatan Andalas
Benign Prostatic Hyperplasia (BPH) is the growth of non-malignant cells or hyperplasia of prostate tissue, which causes Lower Urinary Tract Symptoms (LUTS) in men.
Shakina Reza Waskita, Muslim Andala Putra, Nur Mujadiddah Mochtar, Budi Himawan   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Data spaces as meta-organisations

European Journal of Information Systems
Sharing and reusing data across organisations is central to the European data strategy and its transformation towards creating a data-driven economy. Currently, data sharing, when it occurs, is typically facilitated through centralised platforms or bilateral integration solutions, which are increasingly failing to meet requirements for flexibility ...
Tobias Moritz Guggenberger, Christoph Schlueter Langdon, Boris Otto   +2 more
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Operationalizing and Automating Data Validation in Data Spaces

Data Science and Engineering
Abstract Data spaces have recently emerged as an innovative paradigm for cross-organizational data sharing. These decentralized environments require sophisticated data governance protocols to ensure compliance with data standards, roles and policies.
Hmimou Ham Man, Achraf, Jovanovic, Petar, Nadal Francesch, Sergi, Romero Moral, Óscar, Queralt Calafat, Anna   +4 more
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Elliptic equations with measure data in Orlicz spaces

Electronic Journal of Differential Equations, 2008
This article shows the existence of solutions to the nonlinear elliptic problem $A(u)=f$ in Orlicz-Sobolev spaces with a measure valued right-hand side, where $A(u)=-mathop{ m div}a(x,u, abla u)$ is a Leray-Lions operator defined on a subset of $W_{
Ge Dong
doaj