Results 111 to 120 of about 384,420 (258)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Analysis of the impact of opening and sharing of affiliated green spaces on the accessibility and equal access of green spaces: a case study in Shanghai

Discover Sustainability
Within the context of limited land resources in densely populated urban areas, the opening and sharing of affiliated green spaces have become an innovative way to expand urban green spaces.
Jinyue Yang, Sijun Zheng, Shengpeng Wang, Ruijun Hao, Tintin Fu, Kun He, Ming Yin, Wenqian Ma, Qian Xie   +8 more
doaj   +1 more source

Dataset Similarity Detection for Reuse Protection in Federated Data Spaces with Privacy Considerations

Applied Sciences
Federated data spaces, established through initiatives such as IDSA and GAIA-X, enable organizations to share and monetize datasets under contractual terms.
Christos Panagiotou, Artemios G. Voyiatzis, Kyriakos Stefanidis   +2 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Exploring the Role of Federated Data Spaces in Implementing Twin Transition within Manufacturing Ecosystems. [PDF]

Sensors (Basel), 2023
Jurmu M, Niskanen I, Kinnula A, Kääriäinen J, Ylikerälä M, Räsänen P, Tuikka T.   +6 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Trusted Data Spaces as a Viable and Sustainable Solution for Networks of Population-Based Patient Registries. [PDF]

JMIR Public Health Surveill, 2023
Nicholson N, Caldeira S, Furtado A, Nicholl C.   +3 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Can OpenEHR, ISO 13606, and HL7 FHIR Work Together? An Agnostic Approach for the Selection and Application of Electronic Health Record Standards to the Next-Generation Health Data Spaces. [PDF]

J Med Internet Res, 2023
Pedrera-Jiménez M, García-Barrio N, Frid S, Moner D, Boscá-Tomás D, Lozano-Rubí R, Kalra D, Beale T, Muñoz-Carrero A, Serrano-Balazote P.   +9 more
europepmc   +1 more source