Results 101 to 110 of about 3,370,595 (309)

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

open access: yesMolecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad   +13 more
wiley   +1 more source

Data Structure Fusion

open access: yes, 2010
We consider the problem of specifying data structures with complex sharing in a manner that is both declarative and results in provably correct code. In our approach, abstract data types are specified using relational algebra and functional dependencies; a novel fuse operation on relational indexes specifies where the underlying physical data structure
Hawkins, Peter   +4 more
openaire   +3 more sources

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

Data visualisation approaches for component network meta-analysis: visualising the data structure. [PDF]

open access: yesBMC Med Res Methodol, 2023
Freeman SC   +8 more
europepmc   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Genome assembly composition of the String "ACGT" array: a review of data structure accuracy and performance challenges. [PDF]

open access: yesPeerJ Comput Sci, 2023
Magdy Mohamed Abdelaziz Barakat S   +4 more
europepmc   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

Microstructure evolution of lithium-ion battery electrodes at different states of charge: Deep learning-based segmentation

open access: yesElectrochemistry Communications, 2022
The evolution of the microstructure of a battery electrode is closely related to battery performance. Characterization and visualization of the evolution of the microstructure is essential for optimization of manufactured electrodes.
Yazheng Yang   +9 more
doaj  

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