Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
BIDScoin: A User-Friendly Application to Convert Source Data to Brain Imaging Data Structure. [PDF]
Front Neuroinform, 2021 Zwiers MP, Moia S, Oostenveld R.
europepmc +1 more source
Linear Space Data Structures for Finite Groups with Constant Query-Time [PDF]
, 2022 François Le Gall
openalex +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Issues in adaptive mesh refinement implementation
Electronic Journal of Differential Equations, 2007 Physical phenomena often involve discontinuities and/or localized high-gradient areas. The numerical simulation of these problems and conventional techniques (Finite Elements, Finite Volumes, Finite Differences, and Spectral Methods) with a uniform grid ...
Noureddine Hannoun, Vasilios Alexiades
doaj
Data structure set-trie for storing and querying sets: Theoretical and empirical analysis. [PDF]
PLoS One, 2021 Savnik I +3 more
europepmc +1 more source
Financial flexibility and the speed of target adjustment of capital structure: Panel data analysis
, 2016 Ziad Mohammad Zurigat
openalex +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source