Results 181 to 190 of about 42,049,725 (376)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

The Data Calculator: Data Structure Design and Cost Synthesis from First Principles and Learned Cost Models

open access: yesSIGMOD Conference, 2018
Stratos Idreos   +4 more
semanticscholar   +1 more source

PET-BIDS, an extension to the brain imaging data structure for positron emission tomography. [PDF]

open access: yesSci Data, 2022
Norgaard M   +31 more
europepmc   +1 more source

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