Results 61 to 70 of about 11,352,047 (344)

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Local Kernels and the Geometric Structure of Data [PDF]

, 2015
We introduce a theory of local kernels, which generalize the kernels used in the standard diffusion maps construction of nonparametric modeling. We prove that evaluating a local kernel on a data set gives a discrete representation of the generator of a ...
Berry, Tyrus, Sauer, Timothy
core   +1 more source

Fully dynamic data structure for LCE queries in compressed space [PDF]

, 2016
A Longest Common Extension (LCE) query on a text $T$ of length $N$ asks for the length of the longest common prefix of suffixes starting at given two positions. We show that the signature encoding $\mathcal{G}$ of size $w = O(\min(z \log N \log^* M, N))$
Bannai, Hideo, I, Tomohiro, Inenaga, Shunsuke, Nishimoto, Takaaki, Takeda, Masayuki   +4 more
core   +2 more sources

An Improved Variable Neighborhood Search for the Reconfigurable Assembly Line Reconfiguring Problem

Applied Sciences
Throughout the past several decades, the manufacturing industry has been confronted with rapidly evolving market demands. The Reconfigurable Assembly Line (RAL) changes the quantity and variety of products produced through reconfiguration at different ...
Xiaojun Zhu, Zhigang Xu, Junyi Wang, Xiao Yang   +3 more
doaj   +1 more source

Oblivious Data Structures [PDF]

Proceedings of the 2014 ACM SIGSAC Conference on Computer and Communications Security, 2014
We design novel, asymptotically more efficient data structures and algorithms for programs whose data access patterns exhibit some degree of predictability. To this end, we propose two novel techniques, a pointer-based technique and a locality-based technique.
Liu, C, Shi, E, Wang, XS, Nayak, K, Chan, HTH, Huang, Y, Stefanov, E   +6 more
openaire   +3 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Extracting molecular Hamiltonian structure from time-dependent fluorescence intensity data [PDF]

, 2000
We propose a formalism for extracting molecular Hamiltonian structure from inversion of time-dependent fluorescence intensity data. The proposed method requires a minimum of \emph{a priori} knowledge about the system and allows for extracting a complete ...
Assion A, Baer R, Constantin Brif, Herschel Rabitz, Ho T-S, Iaconis C, Lu Z-M, von Geramb H V, Walmsley I A, Williamson J C, Zewail A H   +10 more
core   +3 more sources

Methodology to identify robots given the type of control designation

Doklady Belorusskogo gosudarstvennogo universiteta informatiki i radioèlektroniki, 2020
Currently, robot manufacturers usually use closed proprietary protocols, which significantly complicates the development and integration of new robots and complexes.
S. A. Arkhipenka, L. U. Shilin, A. A. Naurotsky, A. P. Kuznetsov   +3 more
doaj   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source