Results 61 to 70 of about 3,370,595 (309)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Algomaster Platform Extension for Improved Usability [PDF]

Journal of Electrical and Electronics Engineering, 2017
Visualizations of algorithms and data structures can be effectively used for supporting the teaching process. However, such visualization must be comprehensive for students and still semantically correct.
BENEJ Martin, ŠIMOŇÁK Slavomír
doaj  

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

An Improved Variable Neighborhood Search for the Reconfigurable Assembly Line Reconfiguring Problem

Applied Sciences
Throughout the past several decades, the manufacturing industry has been confronted with rapidly evolving market demands. The Reconfigurable Assembly Line (RAL) changes the quantity and variety of products produced through reconfiguration at different ...
Xiaojun Zhu, Zhigang Xu, Junyi Wang, Xiao Yang   +3 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Near-Optimal Data Structure for Approximate Range Emptiness Problem in Information-Centric Internet of Things

IEEE Access, 2019
The approximate range emptiness problem requires a memory-efficient data structure D to approximately represent a set S of n distinct elements chosen from a large universe U= {0,1,⋯,N-1} and answer an emptiness query of the form “S∩ ...
Xiujun Wang, Zhi Liu, Yan Gao, Xiao Zheng, Xianfu Chen, Celimuge Wu   +5 more
doaj   +1 more source

The Impact of Pair Programming on the Performance of Slow-Paced Students: A Study on Data Structure Courses

Journal of Information and Organizational Sciences, 2020
A study shows that pair programming can help slow-paced students in completing Introductory Programming assessment. This paper replicates the study on Data Structure course, in which the completion of the assessments does not only rely on logic but also ...
Mewati Ayub, Oscar Karnalim, Laurentius Risal, Maresha Caroline Wijanto   +3 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source