Results 101 to 110 of about 6,691,397 (341)

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

open access: yesFEBS Letters, EarlyView.
We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio   +9 more
wiley   +1 more source

Data Structures for SMEM-Finding in the PBWT. [PDF]

open access: yesInt Symp String Process Inf Retr, 2023
Bonizzoni P   +5 more
europepmc   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Data Structures for Halfplane Proximity Queries and Incremental Voronoi Diagrams

open access: yes, 2017
We consider preprocessing a set $S$ of $n$ points in convex position in the plane into a data structure supporting queries of the following form: given a point $q$ and a directed line $\ell$ in the plane, report the point of $S$ that is farthest from (or,
Aronov, Boris   +6 more
core   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

open access: yesFEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki   +4 more
wiley   +1 more source

Visual Algorithm Simulation Exercise System with Automatic Assessment: TRAKLA2

open access: yesInformatics in Education, 2004
Interaction and feedback are key factors supporting the learning process. Therefore many automatic assessment and feedback systems have been developed for computer science courses during the past decade. In this paper we present a new framework, TRAKLA2,
Lauri MALMI   +5 more
doaj   +1 more source

Hierarchical data structures for flowchart. [PDF]

open access: yesSci Rep, 2023
Zhang P, Dou W, Liu H.
europepmc   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

Measuring Students' Acceptance and Confidence on Algorithms and Programming: The Impact of the Engagement with CS on Secondary Education

open access: yesInformatics in Education, 2013
This paper presents results of a questionnaire focused on investigating students' confidence and behavioral intention in the area of programming, particularly that of structures, problem solving, and programming commands (Conditional - Loop).
Spyros DOUKAKIS   +3 more
doaj   +1 more source

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