Results 71 to 80 of about 2,861,627 (269)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Free self-assembly of spontaneously chiral, supramolecular structures

, 2017
In this thesis, Molecular Dynamics simulations are used to investigate the free selfassembly of supramolecular, chiral structures. The main coarse-grained model used for this is the disc-shaped variant of the Gay-Berne potential. This is parameterised to
Dastan, Alireza
core   +1 more source

Investigating Spatial Error Structures in Continuous Raster Data [PDF]

, 2018
The objective of this study is to investigate spatial structures of error in the assessment of continuous raster data. The use of conventional diagnostics of error often overlooks the possible spatial variation in error because such diagnostics report ...
Tsutsumida, N, Tsutsumida, Narumasa, Harris, P, Narumasa Tsutsumida (7629554), Alexis Comber (440055), Balzter, Heiko, Balzter, H, Comber, Alexis, Harris, P., Rodríguez-Veiga, Pedro, Harris, Paul, Comber, A, Heiko Balzter (2614918), Pedro Rodriguez-Veiga (7625795), Baltzer, H, Paul Harris (178628), Rodríguez-Veiga, P   +16 more
core   +1 more source

Hierarchical data structures for flowchart. [PDF]

Sci Rep, 2023
Zhang P, Dou W, Liu H.
europepmc   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

AI for Data Quality Auditing: Detecting Mislabeled Work Zone Crashes Using Large Language Models

Ensuring high data quality in traffic crash datasets is critical for effective safety analysis and policymaking. This study presents an AI-assisted framework for auditing crash data integrity by detecting potentially mislabeled records related to ...
Nirmal Acharya, Elhenawy, Mohammad, Taqwa I. Alhadidi, Jaradat, Shadi, Acharya, Nirmal, Mohammad Elhenawy, Shivshankar, Smitha, Alhadidi, Taqwa I., Smitha Shivshankar, Shadi Jaradat, https://orcid.org/   +10 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

fimpera: drastic improvement of Approximate Membership Query data-structures with counts. [PDF]

Bioinformatics, 2023
Robidou L, Peterlongo P.
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source