Results 81 to 90 of about 347,865 (289)
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
PPSZ is better than you think [PDF]
TheoretiCSPPSZ, for long time the fastest known algorithm for $k$-SAT, works by going through the variables of the input formula in random order; each variable is then set randomly to $0$ or $1$, unless the correct value can be inferred by an efficiently ...
Dominik Scheder
doaj +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
On the Constant-Depth Circuit Complexity of Generating Quasigroups [PDF]
TheoretiCSWe investigate the constant-depth circuit complexity of the Isomorphism Problem, Minimum Generating Set Problem (MGS), and Sub(quasi)group Membership Problem (Membership) for groups and quasigroups (=Latin squares), given as input in terms of their ...
Nathaniel A. Collins +3 more
doaj +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Direct Access for Answers to Conjunctive Queries with Aggregation [PDF]
Logical Methods in Computer ScienceWe study the fine-grained complexity of conjunctive queries with grouping and aggregation. For common aggregate functions (e.g., min, max, count, sum), such a query can be phrased as an ordinary conjunctive query over a database annotated with a suitable
Idan Eldar +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Data Structures & Algorithms: CSC 223
, 2009 Data Structures & Algorithms: CSC 223, Supplementary examinations November ...
Sibanda, K, Chadwick, J
core
The NFA Acceptance Hypothesis: Non-Combinatorial and Dynamic Lower Bounds [PDF]
TheoretiCSWe pose the fine-grained hardness hypothesis that the textbook algorithm for the NFA Acceptance problem is optimal up to subpolynomial factors, even for dense NFAs and fixed alphabets. We show that this barrier appears in many variations throughout the
Karl Bringmann +3 more
doaj +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source