Results 141 to 150 of about 23,419,181 (286)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Functional Requirements for Subject Authority Data (FRSAD) - A Conceptual Model

open access: yes, 2018
The purpose of authority control is to ensure consistency in representing a value - a name of a person, a place name, or a term or code representing a subject - in the elements used as access points in information retrieval.
IFLA Working Group on the Functional Requirements for Subject Authority Records (FRSAR)
core   +1 more source

Training Subjects On Key Concepts From Patient-Reported Outcomes (PROs) Improves Understanding And Data Accuracy

open access: yesPatient Related Outcome Measures, 2019
Nadeeka R Dias,* Amanda R Howley,* Rinah Yamamoto, Susan M Dallabrida Department of Clinical Science and Consulting, eResearch Technology (ERT), Boston, MA, USA*These authors contributed equally to this workCorrespondence: Amanda R HowleyDepartment of ...
Dias NR   +3 more
doaj  

StratLearn-z: Improved photo-$z$ estimation from spectroscopic data subject to selection effects

open access: yesThe Open Journal of Astrophysics
A precise measurement of photometric redshifts (photo-z) is crucial for the success of modern photometric galaxy surveys. Machine learning (ML) methods show great promise in this context, but suffer from covariate shift in training sets due to selection ...
Chiara Moretti   +5 more
doaj   +1 more source

Semiparametric Model for Bivariate Survival Data Subject to Biased Sampling. [PDF]

open access: yesJ R Stat Soc Series B Stat Methodol, 2019
Piao J, Ning J, Shen Y.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Multilingual Subject Retrieval: Bibliotheca Alexandrina’s Subject Authority File and Linked Subject Data

open access: yes, 2015
The Bibliotheca Alexandrina (BA) has been developing its own authority file since September 2006. The file includes subject headings, personal names, corporate bodies, series, and uniform titles. The BA authority file is unique in that it is constructed on the actual collection and it establishes subject headings in the language of the item described ...
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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