Results 71 to 80 of about 27,692,945 (302)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The right to protection of personal data in the EU [PDF]

Strani pravni život, 2018
The violation of the right to privacy and the need for protection has conditioned the development of regulations that govern these issues. The subject of work is the General Data Protection Regulation that the European Union passed in 2016 and will come ...
Prlja Sanja
doaj  

Enhancing Biobank Participants’ Rights – From Paper to Portal

SCRIPTed: A Journal of Law, Technology & Society, 2016
On paper, participants in population biobanks – large-scale collections of human samples and associated health data – enjoy a number of rights such as the right to consent to their participation, to withdraw, to feedback and to view their data (biobank ...
Jasper Bovenberg, Mathijs Kattenberg, Bart Baselmans, Michel Sinke, Remko Hoekstra, Dorret I. Boomsma, Gonneke Willemsen   +6 more
doaj   +1 more source

Rights and the complaint process for people receiving mental health services

, 2003
Title from web page (viewed Nov. 29, 2004).; "Reviewed in 2003."; Harvested from the web on 11/30/04Ohio Legal Rights Service (OLRS) publication, Rights and the Complaint Process for People Receiving Mental Health ...
Ohio Legal Rights Service.
core  

Introducing the Concept of Data Subject Rights as a Service Under the GDPR

, 2023
The General Data Protection Regulation (GDPR) has introduced various data subject rights, e.g., the right of access, the right to erasure, or the right to data portability. These rights empower European individuals, the data subjects, to exercise control
Jensen, Meiko,, Gruschka, Nils,, Hansen, Malte,   +2 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Forest Land Tenure Rights on Indigenous Peoples in Honitetu Village West Seram District, Maluku

Jurnal Sylva Lestari, 2018
Forest land tenure systems for indigenous peoples are always debated by various parties regarding the overlapping interests and rights of forest land. Objective of this study is to analyze the types of indigenous peoples' rights to strengthen forest land
Marthina Tjoa, Didik Suharjito, Hariadi Kartodiharjo, Endriatmo Soetarto   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source