Results 101 to 110 of about 45,779,043 (381)

Empagliflozin Use Is Associated With Lower Risk of All-Cause Mortality, Hospitalization for Heart Failure, and End-Stage Renal Disease Compared to DPP-4i in Nordic Type 2 Diabetes Patients: Results From the EMPRISE (Empagliflozin Comparative Effectiveness and Safety) Study

Journal of Diabetes Research
Conclusion: Empagliflozin initiation was associated with a significantly reduced risk of ACM, HHF, CVM, and ESRD compared with initiation of DPP-4i in patients with T2D when examining routine clinical practice data from Nordic countries.
Gisle Langslet, Thomas Nyström, Dorte Vistisen, Bendix Carstensen, Emilie Toresson Grip, Paula Casajust, Giorgi Tskhvarashvili, Fabian Hoti, Riho Klement, Kristina Karlsdotter, Mikko Tuovinen, Anne Pernille Ofstad, Maria Lajer, Christina Shay, Lisette Koeneman, Soulmaz Fazeli Farsani, Leo Niskanen, Sigrun Halvorsen   +17 more
doaj   +1 more source

SMS design review plan, type 1 data [PDF]

The SMS PDR plan is submitted incrementally 15 days prior to the associated PDR's.

core   +1 more source

On the assimilation of SWOT type data into 2D shallow-water models [PDF]

, 2013
In river hydraulics, assimilation of water level measurements at gauging stations is well controlled, while assimilation of images is still delicate. In the present talk, we address the richness of satellite mapped information to constrain a 2D shallow ...
Couderc, Frédéric, Dartus, Denis, Garambois, Pierre-André, Madec, Ronan, Monnier, Jérôme, Villa, Jean-Paul   +5 more
core  

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

A survey on data compression techniques: From the perspective of data quality, coding schemes, data type and applications

Journal of King Saud University: Computer and Information Sciences, 2021
Uthayakumar Jayasankar, Vengattaraman Thirumal, D. Ponnurangam   +2 more
semanticscholar   +1 more source

Nonlocal boundary value problems with BV-type data

Electronic Journal of Qualitative Theory of Differential Equations, 2020
In this paper we present some existence and uniqueness results for solutions of second order boundary value problems, which are functions of bounded variation along with their derivatives.
Jürgen Appell, Daria Bugajewska, Simon Reinwand   +2 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

DATATOC: a novel conjugate for kit-type 68Ga labelling of TOC at ambient temperature

EJNMMI Radiopharmacy and Chemistry, 2016
Background The widespread acceptance and application of 68Ga-PET depends on our ability to develop radiopharmaceuticals that can be prepared in a convenient and suitable manner.
Johanna Seemann, Bradley Waldron, David Parker, Frank Roesch   +3 more
doaj   +1 more source