Results 151 to 160 of about 15,768,589 (336)

Prediction of Major Adverse Cardiovascular Events From Retinal, Clinical, and Genomic Data in Individuals With Type 2 Diabetes: A Population Cohort Study

, 2022
Ify Mordi, Emanuele Trucco, Mohammad Ghouse Syed, Tom MacGillivray, Adi Nar, Yu Huang, Gittu George, Stephen Hogg, Radha Venkateshan, Vijayaraghavan Prathiba, Ranjit Mohan Anjana, Viswanathan Mohan, Ewan R. Pearson, Chim C. Lang, Alex S. F. Doney, the INSPIRED Investigators   +15 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Recovery of the diffuse correlation spectroscopy data-type from speckle contrast measurements: towards low-cost, deep-tissue blood flow measurements. [PDF]

Biomed Opt Express, 2019
Murali K, Nandakumaran AK, Durduran T, Varma HM.   +3 more
europepmc   +1 more source

Calculation of Evacuation Risk in Fire by Type of Building Use Based on Statistical Data - Study on Criteria of Design Evacuation Risk for Fire Safety Design of Buildings -

, 2011
Yuka Ikehata, Hiroaki Notake, Junichi Yamaguchi, Takeyoshi Tanaka   +3 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Recurrent Neural Networks for Early Detection of Heart Failure From Longitudinal Electronic Health Record Data: Implications for Temporal Modeling With Respect to Time Before Diagnosis, Data Density, Data Quantity, and Data Type. [PDF]

Circ Cardiovasc Qual Outcomes, 2019
Chen R, Stewart WF, Sun J, Ng K, Yan X.
europepmc   +1 more source

Data from Redirecting Gene-Modified T Cells toward Various Cancer Types Using Tagged Antibodies

, 2023
Koji Tamada, Degui Geng, Yukimi Sakoda, Navneeta Bansal, Ratika Srivastava, Zhaoyang Li, Eduardo Dávila   +6 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Statistical Studies on Biochemical Data in View of Sex, Age and Blood Type in AMHTS

, 1981
西山 信男, 山田 均, 堤 明美, 梶山 他喜一, 酒井 正衛, 森 甫   +5 more
openalex   +2 more sources

Standard Description of Common Element Model Data Type Based On XML Schema [PDF]

, 2018
Qi Yang, Zhulin Wang, Hongyun Wang
openalex   +1 more source