Results 191 to 200 of about 15,947,209 (329)

Comparison of LSTM- and GRU-Type RNN Networks for Attention and Meditation Prediction on Raw EEG Data from Low-Cost Headsets [PDF]

Fernando Rivas, J. Enrique Sierra‐García, José María Cámara Nebreda   +2 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Hypoglycemia Beliefs, Impaired Hypoglycemia Awareness, and Severe Hypoglycemia in Insulin-Treated Type 2 Diabetes: Insights From CGM Users. [PDF]

Diabetes Care
Lin YK, Tang H, Ye W, Ratzki-Leewing A, Lee J, de Zoysa N, Amiel SA, Herman WH.   +7 more
europepmc   +1 more source

Causes of early-onset type 1 diabetes: toward data-driven environmental approaches [PDF]

, 2008
Pierre Bougnères, Alain‐Jacques Valleron   +1 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Following the long-term evolution of sp³-type defects in tritiated graphene using Raman spectroscopy. [PDF]

Nanoscale Adv
Zeller G, Schlösser M, Telle HH.
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

The Association Between Race/Ethnicity and Risk of Type 2 Diabetes in Women Varies by BMI: A Pooled Analysis of Individual Data From 15 Cohort Studies. [PDF]

Diabetes Care
Nagai K, Chung HF, Hayashi K, Dobson AJ, Ideno Y, Sandin S, van der Schouw YT, Hardy R, Anderson DJ, Demakakos P, Brunner EJ, Mitchell ES, Woods NF, Eastwood SV, El Khoudary SR, Hedderson MM, Weiderpass E, Mishra GD.   +17 more
europepmc   +1 more source

Referee report. For: Cancer in Kenya: types and infection-attributable. Data from the adult population of two National referral hospitals (2008-2012) [version 4; peer review: 1 approved, 1 approved with reservations, 2 not approved]

, 2019
Delphine Casabonne
openalex   +1 more source