Results 271 to 280 of about 15,477,488 (341)

Enhancing precision in breast cancer diagnosis using Tailored Ratio-Integrated Variance Estimation using Neyman allocation Implementation(TRIVENI). [PDF]

Sci Rep
Triveni GRV, Danish F, Reddy VRK.
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Cell Decoder: decoding cell identity with multi-scale explainable deep learning. [PDF]

Genome Biol
Zhu J, Zhang Z, Xiang Y, Xie B, Dong X, Xie L, Zhou P, Yao R, Wang X, Li Y, He F, Zhu W, Zhang Z, Chang C.   +13 more
europepmc   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Respiratory effects of nusinersen treatment in pediatric patients with spinal muscular atrophy types 2 and 3. [PDF]

Eur J Pediatr
Rochman M, Shay Levanon D, Amirav I, Be'er M, Cahal M, Besor O, Fattal-Valevski A, Lavie M.   +7 more
europepmc   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Wearable device-based health equivalence of different physical activity intensities against mortality, cardiometabolic disease, and cancer. [PDF]

Nat Commun
Biswas RK, Ahmadi MN, Bauman A, Milton K, Koemel NA, Stamatakis E.   +5 more
europepmc   +1 more source

Disuse-induced muscle-type specific alterations and adiponectin pathway response in male mice. [PDF]

Physiol Rep
Sébastien S, Maëlle L, Vincianne J, Anne-Emilie D, Alexandre L, Alexandra T.   +5 more
europepmc   +1 more source

Decoding adult murine pancreatic islet cell diversity through cell type-resolved proteomics and phosphoproteomics. [PDF]

Commun Biol
Thielert M, Villalba A, Brennsteiner V, Wahle M, Ammar C, Brunner AD, Fouque A, Lourenço C, Oshima M, Rachdi L, Staels W, Mann M, Scharfmann R.   +12 more
europepmc   +1 more source

Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. [PDF]

Nat Commun
Green NC, Gao H, Chu X, Yuan Q, McGuire P, Lai D, Jiang G, Xuei X, Reiter JL, Stevens J, Sutherland GT, Goate AM, Pang ZP, Slesinger PA, Hart RP, Tischfield JA, Agrawal A, Wang Y, Duren Z, Edenberg HJ, Liu Y.   +20 more
europepmc   +1 more source