Results 291 to 300 of about 44,292,339 (363)

Lateral Asymmetries in Primary Degenerative Dementia of the Alzheimer Type. A Correlative Study of Cognitive, Haemodynamic and EEG Data, In Relation with Severity, Age of Onset and Sex

, 1990
Pierre Celsis, Alain Agniel, Michèle Puel, Anne Le Tinnier, Gérard Viallard, Jean‐François Démonet, A Rascol, Jean-Pierre Marc-Vergnes   +7 more
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data. [PDF]

Diabetes
Costanzo MC, Akolkar B, Claussnitzer M, Florez JC, Gloyn AL, Grant SFA, Kaestner KH, Manning AK, Mohlke KL, Parker SCJ, Titchenell PM, Udler MS, Jones MA, Kamphaus TN, Fischer RA, McCarthy MI, Miller MR, Boehnke M, AMP T2D Consortium, AMP CMD Consortium, Flannick J, Burtt NP.   +21 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Adaptations and Heterogeneity of Treatment Effects in Platform Trials-Protocol for Two Methodological Studies. [PDF]

Acta Anaesthesiol Scand
Meyhoff TS, Jensen AKG, Perner A, Goligher EC, Campbell MK, Møller MH, Granholm A.   +6 more
europepmc   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression. [PDF]

Eur Heart J
Heimerl M, Erschow S, Müller-Olling M, Manstein DJ, Decher N, Kauferstein S, Jenewein T, Pich A, Ricke-Hoch M, Hilfiker-Kleiner D.   +9 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

scGT:integration algorithm for single-cell RNA-seq and ATAC-seq based on graph transformer. [PDF]

Bioinformatics
Qi Y, Kan Y, Qi J, Jin S.
europepmc   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source