Results 301 to 310 of about 44,292,339 (363)

Variety of sleep and circadian rhythms of elderly dementia patients living in group home residences. [PDF]

Biogerontology
Kubota N, Matsuura N, Ebina M, Suzuki H, Miyagi N, Masukawa N, Kouga F, Yamanaka Y.   +7 more
europepmc   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

A big data driven multilevel deep learning framework for predicting terrorist attacks. [PDF]

Sci Rep
Kalsooma U, Arshad S, Albarah A, Siddiqi I, Ullah S, Mateen A, Amin F.   +6 more
europepmc   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

H2S-mediated protein S-sulfhydration modulates infectivity and autophagy in the rice blast fungus. [PDF]

Nat Commun
Hu H, Qin M, Zhang J, Jiang J, Su Z, Guan L, Qu Z, Liu C, Cai X, Ren Z, Duan Y, Zhang D, Liu H, Zheng L, Huang J, Chen XL.   +15 more
europepmc   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy. [PDF]

Nat Commun
Sun N, Barta H, Chaudhuri S, Chen K, Jin J, Luo H, Yang M, Krigman J, Zhang R, Sanghvi S, Sekine S, Sanders H, Kolonay D, Patel M, Baskin K, Singh H, Zhang P, Xin G, Finkel T.   +18 more
europepmc   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Mrc1 (MMR, CD206) controls the blood proteome in reducing inflammation, age-associated organ dysfunction and mortality in sepsis. [PDF]

Nat Commun
Restagno D, Saraswat M, Aziz PV, Smith K, Roberts AJ, Hintze J, Marth JD.   +6 more
europepmc   +1 more source