Results 111 to 120 of about 1,819,675 (317)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

XSEDE Data Visualization Use Cases L3 Architectural Response

, 2016
This document is the Level 3 Architectural Response for the XSEDE Data Visualization Use Cases.National Science Foundation OCI ...

core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Information visualization on interactive tabletops in work vs. public settings

, 2015
Digital tabletop displays and other large interactive displays have recently become more affordable and commonplace. Due to their benefits for supporting collaborative work—when compared to current desktop-based setups—they will likely be integrated in ...
Hinrichs, Uta, Tobiasz, Matthew, Hancock, Mark, Carpendale, Sheelagh, Isenberg, Petra   +4 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Novel common target genes for breast cancer and colorectal cancer: a Mendelian randomization and spatial transcriptomics study

Discover Oncology
Introduction Breast and colorectal cancer are a major global public health problem. Breast cancer is one of the most common cancers worldwide. Colorectal cancer is the third most common cancer and the second most common cause of tumor death worldwide ...
Pengyu Miao, Zhaokai Zhou, Ling Zhang, Xufeng Huang, Zhengrui Li, Shouxin Wei, András Hajdu   +6 more
doaj   +1 more source

A kinase to cytokine explorer to identify molecular regulators and potential therapeutic opportunities

eLife
Cytokines and chemokines are secreted proteins that regulate various biological processes, such as inflammation, immune response, and cell differentiation. Therefore, disruption of signaling pathways involving these proteins has been linked to a range of
Marina Chan, Yuqi Kang, Shannon Osborne, Michael Zager, Taranjit S Gujral   +4 more
doaj   +1 more source

Collaborative Visualization in the Grid Environment [PDF]

, 2007
Scientific visualization today usually involves scientists from multiple disciplines trying to tackle complex simulation problems or dealing with large datasets.
Wang, Haoxiang
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Visualization by Examples: Mapping Data to Visual Representations using Few Correspondences

, 2022
S.23-32In this paper we propose a new approach for the generation of visual scales for the visualization of scalar and multivariate data. Based on the specification of only a few correspondences between the data set and elements of a space of visual ...
Alexa, M., Müller, W.
core