Results 121 to 130 of about 25,665,833 (303)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Future TransportationThe Faster Region-based Convolutional Network (Faster R-CNN) is an efficient object detection model. However, its large size and significant computational requirements limit its applicability in embedded systems and real-time environments.
Tamás Menyhárt, Róbert Lakatos
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Graphics and Visualization within Cross-Stitch [PDF]
, 1999 The leisure industry, in fields such as the games market, is immersed in computer graphics. However, non-traditional visualization techniques are slow to appear within many leisure pursuits especially cross-stitch.
Atkinson, Karen R., Roberts, Jonathan C.
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A multimodal deep learning architecture for smoking detection with a small data approach
Frontiers in Artificial IntelligenceCovert tobacco advertisements often raise regulatory measures. This paper presents that artificial intelligence, particularly deep learning, has great potential for detecting hidden advertising and allows unbiased, reproducible, and fair quantification ...
Róbert Lakatos +6 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
RoboticsIndustry 4.0 has become one of the most dominant research areas in industrial science today. Many industrial machinery units do not have modern standards that allow for the use of image analysis techniques in their commissioning.
Timotei István Erdei +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source