Results 251 to 260 of about 2,842,615 (341)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The rodent aging interventions database (RAID): a data visualization tool for all studies reporting rodent lifespan extension. [PDF]

Aging (Albany NY)
Peto MV, Floyd AJ, Zealley B, de Grey ADNJ.   +3 more
europepmc   +1 more source

Visualization and Analysis of the Dynamics of Domestic and International Data Asset Research Hotspots

Song Wang, Yijun Chen, Yu Gan
openalex   +2 more sources

A Study of the Numerical Data Compression and Reconstruction for Large-Scale Flow Visualization : A Multi-Level Data Reconstruction

, 2002
Haruo Terasaka, Sensuke Shimizu, Yuriko Takeshima   +2 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

ImageGP 2 for enhanced data visualization and reproducible analysis in biomedical research. [PDF]

Imeta
Chen T, Liu YX, Chen T, Yang M, Fan S, Shi M, Wei B, Lv H, Cao W, Wang C, Cui J, Zhao J, Han Y, Xi J, Zheng Z, Huang L.   +15 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Use of Technology in the Rehabilitation Setting: Therapy Observations, Mixed Methods Analysis, and Data Visualization. [PDF]

Arch Rehabil Res Clin Transl
Celian C, Redd H, Smaller K, Ryali P, Patton JL, Reinkensmeyer DJ, Rafferty MR.   +6 more
europepmc   +1 more source