Results 51 to 60 of about 1,372,066 (309)

A Novel Method for Solving Multiobjective Linear Programming Problems with Triangular Neutrosophic Numbers

Journal of Mathematics, 2021
In the field of operation research, linear programming (LP) is the most utilized apparatus for genuine application in various scales. In our genuine circumstances, the manager/decision-makers (DM) face problems to get the optimal solutions and it even ...
Qing Wang, Yi Huang, Shiming Kong, Xinqiang Ma, Youyuan Liu, S. K. Das, S. A. Edalatpanah   +6 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Investigating the Performance of Retrieval-Augmented Generation and Domain-Specific Fine-Tuning for the Development of AI-Driven Knowledge-Based Systems

Machine Learning and Knowledge Extraction
Generative large language models (LLMs) have revolutionized the development of knowledge-based systems, enabling new possibilities in applications like ChatGPT, Bing, and Gemini.
Róbert Lakatos, Péter Pollner, András Hajdu, Tamás Joó   +3 more
doaj   +1 more source

Examining the Utility of Visible Near-Infrared and Optical Remote Sensing for the Early Detection of Rapid ‘Ōhi‘a Death

Remote Sensing, 2020
The early detection of plant pathogens at the landscape scale holds great promise for better managing forest ecosystem threats. In Hawai‘i, two recently described fungal species are responsible for increasingly widespread mortality in ‘ōhi‘a Metrosideros
Ryan L. Perroy, Marc Hughes, Lisa M. Keith, Eszter Collier, Timo Sullivan, Gabriel Low   +5 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

A Review of Three-Dimensional Medical Image Visualization

Health Data Science, 2022
Importance. Medical images are essential for modern medicine and an important research subject in visualization. However, medical experts are often not aware of the many advanced three-dimensional (3D) medical image visualization techniques that could ...
Liang Zhou, Mengjie Fan, Charles Hansen, Chris R. Johnson, Daniel Weiskopf   +4 more
doaj   +1 more source

Visualizing epigenomic data [PDF]

Nature Methods, 2015
Epigenomics researchers are exploring new ways to visualize the many different types of genome marks.
openaire   +3 more sources