Results 61 to 70 of about 1,691,855 (269)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Improving Cell Detection and Tracking in Microscopy Images Using YOLO and an Enhanced DeepSORT Algorithm

Sensors
Accurate and automated detection and tracking of cells in microscopy images is a persistent challenge in biotechnology and biomedical research. Effective detection and tracking are crucial for understanding biological processes and extracting meaningful ...
Mokhaled N. A. Al-Hamadani, Richard Poroszlay, Gabor Szeman-Nagy, Andras Hajdu, Stathis Hadjidemetriou, Luca Ferrarini, Balazs Harangi   +6 more
doaj   +1 more source

Data visualization and R

, 2014
This workshop focuses on principles and techniques for the visualization of data, with an equal emphasis on theory and implementation. Drawing on classic works by Cleveland (Visualizing Data), Tufte (The Visual Display of Quantitative Information), and Wilkinson (The Grammar of Graphics), a range of best practices for visualization are illustrated ...
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Investigating the Performance of Retrieval-Augmented Generation and Domain-Specific Fine-Tuning for the Development of AI-Driven Knowledge-Based Systems

Machine Learning and Knowledge Extraction
Generative large language models (LLMs) have revolutionized the development of knowledge-based systems, enabling new possibilities in applications like ChatGPT, Bing, and Gemini.
Róbert Lakatos, Péter Pollner, András Hajdu, Tamás Joó   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Annotated Pap cell images and smear slices for cell classification

Scientific Data
Machine learning-based systems have become instrumental in augmenting global efforts to combat cervical cancer. A burgeoning area of research focuses on leveraging artificial intelligence to enhance the cervical screening process, primarily through the ...
David Kupas, Andras Hajdu, Ilona Kovacs, Zoltan Hargitai, Zita Szombathy, Balazs Harangi   +5 more
doaj   +1 more source

Visual interpolation of data

Applied Mathematics Letters, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source