Results 51 to 60 of about 1,819,675 (317)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Combining Stochastic Defenses to Resist Gradient Inversion: An Ablation Study

open access: yesApplied Artificial Intelligence
Gradient Inversion (GI) attacks are a ubiquitous threat in Federated Learning (FL) as they exploit gradient leakage to reconstruct supposedly private training data. Common defense mechanisms such as Differential Privacy (DP) or stochastic Privacy Modules
Daniel Scheliga   +2 more
doaj   +1 more source

Accurate and Computational: A review of color reproduction in Full-color 3D printing

open access: yesMaterials & Design, 2021
As functional 3D printing becomes more popular with industrial manufacturing applications, it is time to start discussing high-fidelity appearance reproduction of 3D objects, particularly in faithful colors.
Jiangping Yuan   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Classification and analysis of the MNIST dataset using PCA and SVM algorithms

open access: yesVojnotehnički Glasnik, 2023
Introduction/purpose: The utilization of machine learning methods has become indispensable in analyzing large-scale, complex data in contemporary data-driven environments, with a diverse range of applications from optimizing business operations to ...
Mokhaled N. A. Al-Hamadani
doaj   +1 more source

Regular Spatial Separation for Exploratory Visualization [PDF]

open access: yes, 2002
There are many well-used techniques in exploratory visualization that select, filter or highlight particular aspects of the visualization to gain a better understanding of the structure and makeup of the underlying information.
Jonathan C. Roberts   +1 more
core   +1 more source

Feature-based visualization of dense integral line data

open access: yes, 2022
S.71-87Feature-based visualization of flow fields has proven as an effective tool for flow analysis. While most flow visualization techniques operate on vector field data, our visualization techniques make use of a different simulation output: Particle ...
Joy, K.I.   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Pixel-wise segmentation of cells in digitized Pap smear images

open access: yesScientific Data
A simple and cheap way to recognize cervical cancer is using light microscopic analysis of Pap smear images. Training artificial intelligence-based systems becomes possible in this domain, e.g., to follow the European recommendation to screen negative ...
Balazs Harangi   +5 more
doaj   +1 more source

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