Results 81 to 90 of about 1,372,066 (309)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Spatiotemporal Dynamics of Water Quality: Long-Term Assessment Using Water Quality Indices and GIS

ISPRS International Journal of Geo-Information
The severe contamination of groundwater supplies in rural areas is a global problem that requires strict environmental measures. Related to this, one of the most important challenges at present is the elimination of local sources of pollution. Therefore,
Dániel Balla, Emőke Kiss, Marianna Zichar, Tamás Mester   +3 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

3D-visualization of tomographic volume data using the generalized voxel-model [PDF]

, 1989
Κ. H. Höhne, M. Bomans, A. Pommert, Martin Riemer, C. Schiers, U. Tiede, G. Wiebecke   +6 more
openalex   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

A multimodal deep learning architecture for smoking detection with a small data approach

Frontiers in Artificial Intelligence
Covert tobacco advertisements often raise regulatory measures. This paper presents that artificial intelligence, particularly deep learning, has great potential for detecting hidden advertising and allows unbiased, reproducible, and fair quantification ...
Róbert Lakatos, Róbert Lakatos, Róbert Lakatos, Péter Pollner, András Hajdu, Tamás Joó, Tamás Joó   +6 more
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Image-to-Image Translation-Based Deep Learning Application for Object Identification in Industrial Robot Systems

Robotics
Industry 4.0 has become one of the most dominant research areas in industrial science today. Many industrial machinery units do not have modern standards that allow for the use of image analysis techniques in their commissioning.
Timotei István Erdei, Tibor Péter Kapusi, András Hajdu, Géza Husi   +3 more
doaj   +1 more source

DeepEye: An Automatic Big Data Visualization Framework

Big Data Mining and Analytics, 2018
Data visualization transforms data into images to aid the understanding of data; therefore, it is an invaluable tool for explaining the significance of data to visually inclined people.
Xuedi Qin, Yuyu Luo, Nan Tang, Guoliang Li   +3 more
doaj   +1 more source