Results 51 to 60 of about 2,604,120 (248)

Examining HPO by organ and system to facilitate practical use by clinicians

Genomics & Informatics
The Human Phenotype Ontology (HPO) is widely used for annotating clinical text data, and sufficient annotation is crucial for the effective utilization of clinical texts.
Eisuke Dohi, Terue Takatsuki, Yuka Tateisi, Toyofumi Fujiwara, Yasunori Yamamoto   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

POTRET KONFLIK AGRARIA DI INDONESIA

BHUMI: Jurnal Agraria dan Pertanahan, 2018
For the last three years (2010-2013) the conflicts on natural and agrarian resources has taken public attention beginning from the Government, Parliement, National Commission on Human Right to Non Governmental Organization as they frequently took place.
Widiyanto Widiyanto
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Interaction of Dislocations and Interfaces in Crystalline Heterostructures: A Review of Atomistic Studies

Crystals, 2019
Interfaces in heterostructures of crystalline materials could strongly affect the slip of dislocations. Such interfaces have become one of the most popular methods to tailor material strength and ductility.
Zhibo Zhang, Cancan Shao, Shuncheng Wang, Xing Luo, Kaihong Zheng, Herbert M. Urbassek   +5 more
doaj   +1 more source

Evaluación crítica y meta-análisis de estudios de variación biológica para albúmina glicosilada, glucosa y HbA1c

Advances in Laboratory Medicine, 2020
A lo largo de los años se han publicado numerosos artículos sobre variación biológica (VB) de diferente calidad. Los objetivos de este trabajo fueron realizar una revisión sistemática y una evaluación crítica de los estudios de VB para albúmina ...
Ricós Carmen, Fernández-Calle Pilar, Gonzalez-Lao Elisabet, Simón Margarida, Díaz-Garzón Jorge, Boned Beatriz, Marqués-García Fernando, Minchinela Joana, Perich Maria Carmen, Tejedor-Ganduxé Xavier, Corte Zoraida, Aarsand Aasne K., Aslan Berna, Carobene Anna, Coskun Abdurrahman, Sandberg Sverre   +15 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Global database of cement production assets and upstream suppliers [PDF]

, 2023
Nataliya Tkachenko, Kevin Tang, Matthew McCarten, Steven Reece, David Kampmann, Conor Hickey, Maral Bayaraa, Peter Foster, Courtney Layman, Cristian Rossi, K. S. Scott, Dave Yoken, Christophe Christiaen, Ben Caldecott   +13 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Prediction of severe immune-related adverse events requiring hospital admission in patients on immune checkpoint inhibitors: study of a population level insurance claims database from the USA [PDF]

, 2021
Mark Kalinich, William S. Murphy, Shannon Wongvibulsin, Vartan Pahalyants, Kun‐Hsing Yu, Chenyue Lu, Feicheng Wang, Leyre Zubiri, Vivek Naranbhai, Alexander Gusev, Shawn G. Kwatra, Kerry L. Reynolds, Yevgeniy R. Semenov   +12 more
openalex   +1 more source