Results 71 to 80 of about 6,912,826 (303)
Bioinformation, 2011 Glaucoma, a complex heterogenous disease, is the leading cause for optic nerve-related blindness worldwide. Primary open angle glaucoma (POAG) is the most common subset and by the year 2020 it is estimated that approximately 60 million people will be affected. MYOC, OPTN, CYP1B1 and WDR36 are the important candidate genes.
Rangachari, K +6 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Enhancing data discovery with contextual pre-filtering
Journal of Big DataIn this paper, entity contextual pre-filtering is proposed to refine dataset relevance assessment and streamline data discovery. Heterogeneous Graph Neural Networks are used to exploit the local context embedded within graph-based schemas.
Javier Flores, Sergi Nadal, Oscar Romero
doaj +1 more source
, 2009 This article reviews the new database released by Brill entitled World Religion Database (WRD).
Dekker, Jennifer
core
A Molecular Biology Database Digest [PDF]
, 2000 Computational Biology or Bioinformatics has been defined as the application of mathematical and Computer Science methods to solving problems in Molecular Biology that require large scale data, computation, and analysis [18].
Bry, François, Kröger, Peer
core +2 more sources
Nature Cell Biology, 2006 Although the flood of cell biological knowledge rises relentlessly, many databases face an uncertain future. Unless funding for essential bioinformatic resources is set in stone, the next storm may wash away the foundation of future cell biology research.
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
BMC Medical Informatics and Decision MakingBackground Virtual Gene Panels (VGP) comprising disease-associated causal genes are utilized in the diagnosis of rare genetic diseases to evaluate candidate genes identified by whole-genome and whole-exome sequencing.
Jaemoon Shin +3 more
doaj +1 more source
HydrobiologyLarge rivers are difficult to sample due to their size yet critical to monitor because humans heavily rely upon and alter them. Aquatic invertebrates are commonly used to assess the ecosystem quality of streams, but methods to sample large rivers are ...
Lusha M. Tronstad, Bryan P. Tronstad
doaj +1 more source
TogoVar: A comprehensive Japanese genetic variation database
Human Genome Variation, 2022 Genomic database: Genetic variation patterns in Japan A comprehensive database of genome sequence differences found in Japanese individuals is helping researchers uncover the genetic basis of diseases occurring in the Japanese population.
Nobutaka Mitsuhashi +6 more
doaj +1 more source