Results 81 to 90 of about 6,882,714 (305)

Expanding the concept of ID conversion in TogoID by introducing multi-semantic and label features

Journal of Biomedical Semantics
Background TogoID ( https://togoid.dbcls.jp/ ) is an identifier (ID) conversion service designed to link IDs across diverse categories of life science databases.
Shuya Ikeda, Kiyoko F. Aoki-Kinoshita, Hirokazu Chiba, Susumu Goto, Masae Hosoda, Shuichi Kawashima, Jin-Dong Kim, Yuki Moriya, Tazro Ohta, Hiromasa Ono, Terue Takatsuki, Yasunori Yamamoto, Toshiaki Katayama   +12 more
doaj   +1 more source

Assessing Methods to Monitor Aquatic Invertebrates in a Large River: Comparing Rock Baskets and Hess Samplers in the Snake River, Wyoming, USA

Hydrobiology
Large rivers are difficult to sample due to their size yet critical to monitor because humans heavily rely upon and alter them. Aquatic invertebrates are commonly used to assess the ecosystem quality of streams, but methods to sample large rivers are ...
Lusha M. Tronstad, Bryan P. Tronstad
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Ontology-based expansion of virtual gene panels to improve diagnostic efficiency for rare genetic diseases

BMC Medical Informatics and Decision Making
Background Virtual Gene Panels (VGP) comprising disease-associated causal genes are utilized in the diagnosis of rare genetic diseases to evaluate candidate genes identified by whole-genome and whole-exome sequencing.
Jaemoon Shin, Toyofumi Fujiwara, Hirotomo Saitsu, Atsuko Yamaguchi   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Non-suicidal self-injury and other key predictors of suicide deaths among children and adolescents in England: a population-based case-control study

BMC Medicine
Background Suicide is a leading cause of mortality in young people globally. A history of prior self-harm, with or without suicidal intent, is associated with increased risks of future suicide attempts (SAs) or suicides.
Ben Hoi-Ching Wong, David Odd, Karen Luyt, Vicky Sleap, Sylvia Stoianova, Tom Williams, Samantha Drew, Camilla Parker, Joan Asarnow, Dennis Ougrin   +9 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Legal Threats Database

, 2007
The Legal Threats Database is a catalog of the growing number of lawsuits, cease and desist letters, and other legal challenges faced by those engaging in online speech.

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Examining HPO by organ and system to facilitate practical use by clinicians

Genomics & Informatics
The Human Phenotype Ontology (HPO) is widely used for annotating clinical text data, and sufficient annotation is crucial for the effective utilization of clinical texts.
Eisuke Dohi, Terue Takatsuki, Yuka Tateisi, Toyofumi Fujiwara, Yasunori Yamamoto   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source