Results 71 to 80 of about 8,999,941 (280)

ANIA:ANnotation and Integrated Analysis of the 14-3-3 interactome [PDF]

, 2014
The dimeric 14-3-3 proteins dock onto pairs of phosphorylated Ser and Thr residues on hundreds of proteins, and thereby regulate many events in mammalian cells.
Baskaran, Bastea, Bier, Carol MacKintosh, Cock, Cohen, Dickerson, Dinkel, Dubois, Edgar, Forbes, Fábio Madeira, Gavuthami Murugesan, Gerta Hoxhaj, Graves, Green, Hornbeck, Hu, Huang da, Huminiecki, Ichimura, Johnson, Johnson, Kasahara, Katoh, Konig, Larance, Larkin, Linding, Makino, Manning, Michele Tinti, Molzan, Notredame, Obenauer, Ostlund, Panni, Pearce, Rachel Toth, Robens, Sievers, Silhan, Tinti, Uhart, UniProt Consortium, Waterhouse, Yaffe, Yaffe, Zanivan, Zanivan, Zhang, Zhao   +51 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

DAVID: Database for Annotation, Visualization, and Integrated Discovery

Genome Biology, 2003
The distributed nature of biological knowledge poses a major challenge to the interpretation of genome-scale datasets, including those derived from microarray and proteomic studies.
Glynn Dennis, Brad T. Sherman, Douglas A. Hosack, Jun Yang, Wei Gao, H. C. Lane, R. Lempicki   +6 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Improving average ranking precision in user searches for biomedical research datasets

, 2017
Availability of research datasets is keystone for health and life science study reproducibility and scientific progress. Due to the heterogeneity and complexity of these data, a main challenge to be overcome by research data management systems is to ...
Gaudinat, Arnaud, Gobeill, Julien, Mottin, Luc, Ruch, Patrick, Teodoro, Douglas, Vachon, Thérèse   +5 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Experiment Databases [PDF]

, 2010
Inductive databases are usually viewed as databases that contain models, next to data, such that mining the data essentially boils down to querying them for models. This unifies data mining with database querying. In his chapter, we consider experiment databases.
Vanschoren, Joaquin, Blockeel, Hendrik
openaire   +1 more source

Ribosomal Database Project: data and tools for high throughput rRNA analysis

Nucleic Acids Res., 2013
Ribosomal Database Project (RDP; http://rdp.cme.msu.edu/) provides the research community with aligned and annotated rRNA gene sequence data, along with tools to allow researchers to analyze their own rRNA gene sequences in the RDP framework.
J. Cole, Qiong Wang, Jordan A. Fish, Benli Chai, Donna M. McGarrell, Yanni Sun, C. Brown, Andrea Porras‐Alfaro, C. Kuske, J. Tiedje   +9 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Database independent Migration of Objects into an Object-Relational Database [PDF]

, 2002
This paper reports on the CERN-based WISDOM project which is studying the serialisation and deserialisation of data to/from an object database (objectivity) and ORACLE 9i.Comment: 26 pages, 18 figures; CMS CERN Conference Report ...
Ali, Arshad, Hassan, M. Waseem, McClatchey, R., Munir, Kamran, Willers, I.   +4 more
core   +1 more source