Results 81 to 90 of about 2,545,510 (297)
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo+8 more
wiley +1 more source
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine+10 more
wiley +1 more source
Automated Rooftop Solar Panel Detection Through Convolutional Neural Networks
Transforming the global energy sector from fossil-fuel based to renewable energy sources is crucial to limiting global warming and achieving climate neutrality.
Simon Pena Pereira+2 more
doaj +1 more source
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song+11 more
wiley +1 more source
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton+17 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
Curated databases are databases that are populated and updated with a great deal of human effort. Most reference works that one traditionally found on the reference shelves of libraries -- dictionaries, encyclopedias, gazetteers etc. -- are now curated databases.
Buneman, Peter+3 more
openaire +4 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias+12 more
wiley +1 more source
STDBII, a Database for Storing, Retrieving and Analyzing Spin Trapping Data On an IBM or Macintosh Personal Computer [PDF]
Anson S. W. Li, Colin F. Chignell
openalex +1 more source
Cloud Database Database as a Service [PDF]
Cloud computing has been the most adoptable technology in the recent times, and the database has also moved to cloud computing now, so we will look into the details of database as a service and its functioning. This paper includes all the basic information about the database as a service.
openaire +1 more source