Results 41 to 50 of about 219,510 (306)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
ENVIRONMENTAL MONITORING IN SIBERIA: APPROACHES TO CREATION OF DATABASE OF DANGEROUS WEATHER EVENTS [PDF]
Vestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2016 The method of subject adjustment of data of many years’ monitoring of meteorological and radiation values in urban environment was developed. Proposed method of subject adjustment of monitoring data serves to creation and updating of database of ionizing
P. M. Nagorskiy +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Database “Biography” – a New Information Resource of the State Public Historical Library of Russia
Библиосфера, 2022 The article is devoted to a new information resource of the State Public Historical Library of Russia (SHPL) – the Biography database, which takes into account publications of a biographical and iconographic nature in pre-revolutionary periodicals.
K. A. Shaposhnikov
doaj +1 more source
Creation of a children’s speech database [PDF]
The Journal of the Acoustical Society of America, 1995 Speech was recorded from a large number of children ages 5 through 18 years inclusive, at a custom installation at the St. Louis Science Center. Two separate sets of recordings were made: (1) using a high-fidelity microphone, and (2) using one of five telephone handsets.
James D. Miller +5 more
openaire +1 more source
Computer Vision and the Creation of a Database of Printers’ Ornaments
Digital Humanities Quarterly, 2021 This article describes the creation of a database of over 1 million images of eighteenth-century printers’ ornaments (or fleurons) using computer vision, and how the database was refined using machine learning. The successes and limitations of the method used are discussed, and the purpose of the database for research in the humanities is outlined. The
Hazel Wilkinson +2 more
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Identification of Borrelia species after creation of an in-house MALDI-TOF MS database.
PLoS ONE, 2014 Lyme borreliosis (LB) is a multisystemic disease caused by Borrelia burgdorferi sensu lato (sl) complex transmitted to humans by Ixodes ticks. B. burgdorferi sl complex, currently comprising at least 19 genospecies, includes the main pathogenic species ...
Adriana Calderaro +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source