Results 101 to 110 of about 15,215,863 (336)
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
USE OF DATABASE FORPROJECTION OF DIRECT CURRENT ENGINESFOR MECHANISM DRIVING [PDF]
Analele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2018 The project of a knowledge databaseof anexpert system is difficultentailing a close collaborationof human expert with theknowledge engineer. The result of such collaborationdeterminesthe accuracy of solutions obtainedby the expert system.
Anca-Olimpia Mosneaga (Talaat-Hamid) +1 more
doaj
Differential Privacy for Growing Databases [PDF]
arXiv, 2018 We study the design of differentially private algorithms for adaptive analysis of dynamically growing databases, where a database accumulates new data entries while the analysis is ongoing. We provide a collection of tools for machine learning and other types of data analysis that guarantee differential privacy and accuracy as the underlying databases ...
arxiv
Facilitating evolution in relational database design : a procedure to evaluate and refine novice database designers' schemata : a thesis presented in partial fulfilment of the requirements for the degree of Master of Business Studies in Information Systems at Massey University [PDF]
, 1996 Relational database management systems (RDBMS) have become widely used by many industries in recent years. Latterly these systems have begun to expand their market by becoming readily available at minimal cost to most users of modern computing technology.
Ryder, Michael Robert
core
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Contributions to Logical Database Design [PDF]
Informatică economică, 2012 This paper treats the problems arising at the stage of logical database design. It comprises a synthesis of the most common inference models of functional dependencies, deals with the problems of building covers for sets of functional dependencies, makes
Vitalie COTELEA
doaj
Clinical significance of stratifying prostate cancer patients through specific circulating genes
Molecular Oncology, EarlyView.We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian +12 more
wiley +1 more source
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Investigation of IGES for CAD/CAE data transfer [PDF]
In a CAD/CAE facility there is always the possibility that one may want to transfer the design graphics database from the native system to a non-native system. This may occur because of dissimilar systems within an organization or a new CAD/CAE system is
Zobrist, George W.
core +1 more source
Potentially Polluting Marine Sites GeoDB: An S-100 Geospatial Database as an Effective Contribution to the Protection of the Marine Environment [PDF]
, 2012 Potentially Polluting Marine Sites (PPMS) are objects on, or areas of, the seabed that may release pollution in the future. A rationale for, and design of, a geospatial database to inventory and manipu-late PPMS is presented.
Alexander, Lee +2 more
core +3 more sources