Results 31 to 40 of about 3,292,616 (334)

DEVELOPMENT OF CONCEPTUAL AND LOGICAL MODEL OF INFORMATION SYSTEM FOR INTERNS

open access: yesВестник Северо-Кавказского федерального университета, 2022
The relevance of the problem is due to the need to create a comprehensive solution for the automation of training and testing of employees of enterprises, which are carried out directly within the specific tasks of the organization.
Svetlana Mirskaya
doaj  

Design of Database Exams Problem Collecting in STMIK Jakarta STI & K [PDF]

open access: yes, 2008
Trials are things can not be separated from the world of education, especially in STMIK Jakarta STI & K, so the matter was set to be routine for lecturers.
Dimas, P. R. (Pradhitya)
core  

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy   +5 more
wiley   +1 more source

H2O: An Autonomic, Resource-Aware Distributed Database System [PDF]

open access: yes, 2010
This paper presents the design of an autonomic, resource-aware distributed database which enables data to be backed up and shared without complex manual administration.
Dearle, Alan   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Relational Logic Database Design Model of Information System Control Project in Pt.istaka Karya [PDF]

open access: yes, 1990
Analyzing this data is to provide a clearer picture about the functions of the dataelement or attribute is being investigated. After it was done depiction of therelationship (relationship) of an existing entity such entities.
Djoko Harmantyo, DR., M.Sc Djoko Harmantyo, DR., M.Sc   +1 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

DATABASE FOR THE PURPOSE OF INTEGRATED COASTAL ZONE MANAGEMENT

open access: yesTASK Quarterly, 2000
The database was created in response to the need of obtaining complex information necessary for efficient management of the Polish coastal zone. Database preparation processes are coordinated within the EU PHARE project focusing on harmonising such ...
JULIUSZ GAJEWSKI   +2 more
doaj  

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