Results 71 to 80 of about 3,287,729 (314)

Effectiveness of 2D fingerprints for scaffold hopping

, 2011
Background: It has been suggested that similarity searching using 2D fingerprints may not be suitable for scaffold hopping. Methods: This article reports a detailed evaluation of the effectiveness of six common types of 2D fingerprints when they are used
Gardiner, E.J., Holliday, J.D., O'Dowd, C., Willett, P.   +3 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Synthesis using speaker adaptation from speech recognition DB [PDF]

, 2010
This paper deals with the creation of multiple voices from a Hidden Markov Model based speech synthesis system (HTS). More than 150 Catalan synthetic voices were built using Hidden Markov Models (HMM) and speaker adaptation techniques.
Bonafonte Cávez, Antonio, Moreno Bilbao, M. Asunción, Oller Moreno, Sergio   +2 more
core  

Design Principles for Scaling Multi-core OLTP Under High Contention

, 2016
Although significant recent progress has been made in improving the multi-core scalability of high throughput transactional database systems, modern systems still fail to achieve scalable throughput for workloads involving frequent access to highly ...
Abadi, Daniel J., Faleiro, Jose M., Ren, Kun   +2 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Time-course transcriptome data of silk glands in day 0–7 last-instar larvae of Bombyx mori (w1 pnd strain)

Scientific Data
Time-course transcriptome expression data were constructed for four parts of the silk gland (anterior, middle, and posterior parts of the middle silk gland, along with the posterior silk gland) in the domestic silkworm, Bombyx mori, from days 0 to 7 of ...
Yudai Masuoka, Akiya Jouraku, Takuya Tsubota, Hiromasa Ono, Hirokazu Chiba, Hideki Sezutsu, Hidemasa Bono, Kakeru Yokoi   +7 more
doaj   +1 more source

استخدام الحاسبات الالكترونية في المرور

Iraqi Journal for Computers and Informatics, 1980
استخدام الحاسبات الالكترونية في ...
محمد زكي محمد خضر
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

USING DATABASES TO DESIGN BEARINGS EMPLOYED IN THE CONSTRUCTION OF MECHANISMS [PDF]

Fiabilitate şi Durabilitate, 2018
Designing the knowledge database of an expert system is a difficult task that requires a close cooperation between a human expert and the knowledge engineer.
Anca-Olimpia MOSNEAGA, Iosif TEMPEA
doaj  

تحليل وتصميم نظام الي لتسجيل السيارات

Iraqi Journal for Computers and Informatics, 1978
يتناول هذا البحث نظام تسجيل السيارات وتجديد اجازات التسجيل ، وتتمثل غايتنا في ايجاد الحلول المناسبة لهذا الجانب ، وذلك من خلال التحليل الاحصائي للنظام الحالي ، ومحاولة السيطرة على عامل الوقت و تخفيف الازدحام ، ومن ثم اقتراح نظام جديد يستند على نظام ...
سرمد جورج, هلال عبود تقي   +1 more
doaj   +1 more source