Results 71 to 80 of about 3,292,616 (334)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Deriving Triggers from Integrity Constraint Specifications in the Database Management Systems
Acta Polytechnica, 2001 Supporting integrity constraints is essential for database systems. Integrity constraints are used to ensure that the data in a database complies with rules that have been set to establish accurate and acceptable information for a database.
M. Badawy, K. Richta
doaj
Applied System InnovationThis research proposes the development of an Entity-Relationship Diagram—PRO (ERD-PRO) to assist students in understanding the concept of developing Entity-Relationship Diagrams in designing a database.
S. M. F. D. Syed Mustapha
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Synthesis using speaker adaptation from speech recognition DB [PDF]
, 2010 This paper deals with the creation of multiple voices from a Hidden Markov Model based speech synthesis system (HTS). More than 150 Catalan synthetic voices were built using Hidden Markov Models (HMM) and speaker adaptation techniques.
Bonafonte Cávez, Antonio +2 more
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Design of a phonetic corpus for speech recognition in catalan [PDF]
, 1998 In this paper, we present the design of a corpus for speech recognition to be used for the recording of a speech database in Catalan. A previous database in Spanish was the reference in setting the specifications about the characteristics of the ...
Esquerra Llucià, Ignasi +3 more
core
Effectiveness of 2D fingerprints for scaffold hopping
, 2011 Background: It has been suggested that similarity searching using 2D fingerprints may not be suitable for scaffold hopping. Methods: This article reports a detailed evaluation of the effectiveness of six common types of 2D fingerprints when they are used
Gardiner, E.J. +3 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source