Results 71 to 80 of about 1,281,790 (260)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
USING DATABASES TO DESIGN BEARINGS EMPLOYED IN THE CONSTRUCTION OF MECHANISMS [PDF]
Fiabilitate şi Durabilitate, 2018 Designing the knowledge database of an expert system is a difficult task that requires a close cooperation between a human expert and the knowledge engineer.
Anca-Olimpia MOSNEAGA, Iosif TEMPEA
doaj
استخدام الحاسبات الالكترونية في المرور
Iraqi Journal for Computers and Informatics, 1980 استخدام الحاسبات الالكترونية في ...
محمد زكي محمد خضر
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
تحليل وتصميم نظام الي لتسجيل السيارات
Iraqi Journal for Computers and Informatics, 1978 يتناول هذا البحث نظام تسجيل السيارات وتجديد اجازات التسجيل ، وتتمثل غايتنا في ايجاد الحلول المناسبة لهذا الجانب ، وذلك من خلال التحليل الاحصائي للنظام الحالي ، ومحاولة السيطرة على عامل الوقت و تخفيف الازدحام ، ومن ثم اقتراح نظام جديد يستند على نظام ...
سرمد جورج +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
USE OF DATABASE FORPROJECTION OF DIRECT CURRENT ENGINESFOR MECHANISM DRIVING [PDF]
Analele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2018 The project of a knowledge databaseof anexpert system is difficultentailing a close collaborationof human expert with theknowledge engineer. The result of such collaborationdeterminesthe accuracy of solutions obtainedby the expert system.
Anca-Olimpia Mosneaga (Talaat-Hamid) +1 more
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