Results 91 to 100 of about 781,099 (258)
Epidemiology of high-energy trauma in Chile: An ecological analysis using public registries
MedwaveHigh-energy trauma is defined as severe organic injuries resulting from events that generate a large amount of kinetic, electrical, or thermal energy. It represents a significant public health concern, accounting for 10% of global mortality. This article
Maximiliano Barahona +4 more
doaj +1 more source
Architecture of Automated Database Tuning Using SGA Parameters [PDF]
Database Systems Journal, 2012 Business Data always growth from kilo byte, mega byte, giga byte, tera byte, peta byte, and so far. There is no way to avoid this increasing rate of data till business still running.
Hitesh KUMAR SHARMA +2 more
doaj
Security Issues in Mobile Database Access [PDF]
, 1999 Mobile computing and communication is a rapidly developing area. But mobility is associated with problems for security and privacy beyond those in open networks. A well known threat is tracking user movements. New risks are caused by the mobility of users, the portability of computers, and wireless links which include dynamics, resource dependencies ...
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Trends in Zombie Firms Research: A Bibliographic Review
Studies in Business and EconomicsThe aim of the paper is to explore the knowledge infrastructure of research addressing the zombie issue using a bibliometric review approach combined with content analysis.
Blažková Ivana +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The 27th annual Nucleic Acids Research database issue and molecular biology database collection. [PDF]
Nucleic Acids Res, 2020 Rigden DJ, Fernández XM.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A dataset of the representatives elected in France during the fifth republicZenodo
Data in BriefThe electoral system is a cornerstone of democracy, shaping the structure of political competition, representation, and accountability. In the case of France, it is difficult to access data describing elected representatives, though, as they are ...
Noémie Févrat +3 more
doaj +1 more source