Results 71 to 80 of about 781,099 (258)
DATABASE DEVELOPMENT IN TOXICOGENOMICS: ISSUES AND EFFORTS
Environmental Health Perspectives, 2004 The marriage of toxicology and genomics has created not only opportunities but also novel informatics challenges. As with the larger field of gene expression analysis, toxicogenomics faces the problems of probe annotation and data comparison across different array platforms.
William B, Mattes +4 more
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The 2023 Nucleic Acids Research Database Issue and the online molecular biology database collection. [PDF]
Nucleic Acids Res, 2023 Rigden DJ, Fernández XM.
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Role of Social Capital in Avoiding Over-education [PDF]
Revista Română de Sociologie, 2013 In post-socialist countries, overqualification is a current and relevant issue, butdespite its importance, this topic is not sufficiently addressed in the literature,especially in the post-communist region.
BLANKA BALINT
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The 2021 Nucleic Acids Research database issue and the online molecular biology database collection. [PDF]
Nucleic Acids Res, 2021 Rigden DJ, Fernández XM.
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Thematic Cartography and Databases Visualization [PDF]
Acta Montanistica Slovaca, 2011 Each cartographic work must show topographic or thematic information about the area and its parts, so that the means of expression usedin it support its function and purpose.
Ladislav Plánka
doaj