Results 101 to 110 of about 1,088,169 (316)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Region-based indexing in an image database [PDF]
, 1997 Image retrieval systems based on the image-query-by-example paradigm locate their answer set using a similarity measure of the query image with all images stored in the database. Although this approach generally works for quick re-location of `identical'
Nes, Niels +5 more
core
Recency-Bounded Verification of Dynamic Database-Driven Systems
, 2016 We propose a formalism to model database-driven systems, called database manipulating systems (DMS). The actions of a DMS modify the current instance of a relational database by adding new elements into the database, deleting tuples from the relations ...
Parosh Aziz Abdulla +9 more
core +1 more source
Jurnal Ilmiah Wahana Akuntansi, 2019 This Community Service activities are carried out using the substantive developing database approach to assertions - accounting management assertions of intangible assets recorded in the State - Owned Financial Management Information System (SIMAK BMN ...
Petrolis Nusa Perdana
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Evolving database systems : a persistent view
, 2011 Submitted to POS7 This work was supported in St Andrews by EPSRC Grant GR/J67611 "Delivering the Benefits of Persistence"Orthogonal persistence ensures that information will exist for as long as it is useful, for which it must have the ability to evolve ...
Morrison, R. +3 more
core
Journal of Marine Science and EngineeringThe growing complexity of maritime navigation creates safety challenges that drive the shift toward autonomous systems. Maritime vessel behaviour modelling is critical for safe and efficient autonomous operations.
Ghassan Al-Falouji +6 more
doaj +1 more source
A Database System with Amnesia. [PDF]
, 2017 Big Data comes with huge challenges. Its volume and velocity makes handling, curating, and analytical processing a costly affair. Even to simply “look at” the data within an a priori defined budget and with a guaranteed interactive response time might be impossible to achieve.
M.L. Kersten (Martin) +1 more
openaire +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source