Results 91 to 100 of about 5,268,956 (336)

HAGR: the Human Ageing Genomic Resources [PDF]

open access: yes, 2004
The Human Ageing Genomic Resources (HAGR) is a collection of online resources for studying the biology of human ageing. HAGR features two main databases: GenAge and AnAge. GenAge is a curated database of genes related to human ageing.
Costa, Joana   +2 more
core   +2 more sources

PPNID : a reference database and molecular identification pipeline for plant-parasitic nematodes [PDF]

open access: yes, 2020
Motivation: The phylum Nematoda comprises the most cosmopolitan and abundant metazoans on Earth and plant-parasitic nematodes represent one of the most significant nematode groups, causing severe losses in agriculture.
Bert, Wim   +5 more
core   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

open access: yesFEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker   +9 more
wiley   +1 more source

Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases.

open access: yesJournal of Clinical Investigation, 2019
Parkinson's disease (PD) is a common neurodegenerative disease that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels are common features of PD.
R. Cai   +18 more
semanticscholar   +1 more source

Towards a bioinformatics platform for the Musa research community : [Abstract W076] [PDF]

open access: yes, 2010
Current experiments in genomics produce a large amount of data that needs to be organized into databases and broadly accessible. Like other species, the Musa genomics community would benefit from centralized and innovative ways to study its genome.
Argout, Xavier   +8 more
core  

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

INFORMATIONAL RESOURCES ON POTATO GERMPLASM COLLECTIONS

open access: yesВавиловский журнал генетики и селекции, 2018
The potato (Solanum tuberosum L.) is one of the most important food crops, the advantage of which is the ability to give a high yield in a wide range of agroecosystems, high specific production of dry weight per unit of cultivated area.
D. A. Afonnikov   +2 more
doaj   +1 more source

MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search

open access: yesNucleic Acids Res., 2016
The MalaCards human disease database (http://www.malacards.org/) is an integrated compendium of annotated diseases mined from 68 data sources. MalaCards has a web card for each of ∼20 000 disease entries, in six global categories.
N. Rappaport   +9 more
semanticscholar   +1 more source

DNA, Data and Ethics [PDF]

open access: yes, 2006
The biophysical differences between different kinds of DNA data banks are described. The different ethical implications of DNA fingerprint data banks, data banks of known gene sequences, and data banks of total genomic sequences are considered.
Stewart, J.A.
core  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

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