Results 101 to 110 of about 2,679,408 (299)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Opportunities and Challenges for Genetic Studies of End-Stage Renal Disease in Canada
Canadian Journal of Kidney Health and Disease, 2018 Purpose of review: Genetic testing can improve diagnostic precision in some patients with end-stage renal disease (ESRD) providing the potential for targeted therapy and improved patient outcomes.
Vinusha Kalatharan +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2018 OE-Databases are the spike sorting and clustering of rats' cells included in the study. Nex-Database are the Neuroexplorer files containing neurons timestamps and positions of the animals which allow us to perform cells analysis.
Aude Retailleau (424991)
core +2 more sources
ETHICAL ASPECTS OF HUMAN GENETIC DATABASES: DISTINCTIONS ON THE NATURE, PROVISION, AND OWNERSHIP OF GENETIC INFORMATION [PDF]
Trames, 2004 Antonio Casado da Rocha
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Rule Discovery with a Parallel Genetic Algorithm [PDF]
, 2000 An important issue in data mining is scalability with respect to the size of the dataset being mined. In the paper we address this issue by presenting a parallel GA for rule discovery.
Araujo, Dieferson L.A. +2 more
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Clinical and Experimental Gastroenterology, 2020 Sachin Mohan,1– 3 Shaffer Mok,4 Thomas Judge5 1Department of Gastroenterology and Hepatology, University of Minnesota School of Medicine, St Paul, MN, USA; 2Regions Hospital, Department of Gastroenterology and Hepatology, St Paul, MN, USA; 3Health ...
Mohan S, Mok S, Judge T
doaj