Results 91 to 100 of about 5,302,158 (304)
Conservation of genetic resources in the Cucurbitaceae family in Bulgaria
Растениевъдни науки, 2013 A rich collection of 2014 local and introduced accessions from Cucurbitaceae family is supported at the Institute of Plant Genetic Resources in Sadovo. Local forms are collected from different regions in North and South Bulgaria.
Stefan Neykov +3 more
doaj
Human Mutation, 2012 The inherited cerebellar ataxias are a diverse group of clinically and genetically heterogeneous neurodegenerative disorders. Inheritance patterns of these disorders can be complex with autosomal dominant, autosomal recessive, X‐linked, and mitochondrial
J. Hersheson, A. Haworth, H. Houlden
semanticscholar +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Rule Discovery with a Parallel Genetic Algorithm [PDF]
, 2000 An important issue in data mining is scalability with respect to the size of the dataset being mined. In the paper we address this issue by presenting a parallel GA for rule discovery.
Araujo, Dieferson L.A. +2 more
core
Incremental multiple objective genetic algorithms
, 2004 This paper presents a new genetic algorithm approach to multi-objective optimization problemsIncremental Multiple Objective Genetic Algorithms (IMOGA).
Chen, Q, Guan, SU, Chen, Q., Guan, S.-U.
core +1 more source
Research applications of primary biodiversity databases in the digital age
bioRxiv, 2019 We are in the midst of unprecedented change—climate shifts and sustained, widespread habitat degradation have led to dramatic declines in biodiversity rivaling historical extinction events.
J. Ball-Damerow +8 more
semanticscholar +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Clinical MedicineIntroduction: Cisplatin is a widely used chemotherapeutic agent for treating various malignancies. However, its clinical utility is often restricted by toxicities, such as nephrotoxicity, neurotoxicity and ototoxicity.1 Identifying genetic factors ...
Suvam Banerjee
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
DNA databanks and consent: A suggested policy option involving an authorization model
BMC Medical Ethics, 2003 Background Genetic databases are becoming increasingly common as a means of determining the relationship between lifestyle, environmental exposures and genetic diseases.
Daar Abdallah +2 more
doaj +1 more source