Results 121 to 130 of about 5,302,158 (304)

Genetic Databases and Protection of Genetic Data

, 2023
Genetic Databases and Protection of Genetic Data Abstract This thesis deals with the processing of genetic data obtained by DNA sequencing. The data obtained from the human genome represents a revolutionary basis for scientific research and open the way ...
Vozanková, Anna
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Pathway-Based Drug Repositioning for Breast Cancer Molecular Subtypes

Frontiers in Pharmacology, 2018
Breast cancer is a major public health problem which treatment needs new pharmacological options. In the last decades, during the postgenomic era new theoretical and technological tools that give us novel and promising ways to address these problems have
Raúl A. Mejía-Pedroza, Jesús Espinal-Enríquez, Jesús Espinal-Enríquez, Enrique Hernández-Lemus, Enrique Hernández-Lemus   +4 more
doaj   +1 more source

NIASGBdb: NIAS Genebank databases for genetic resources and plant disease information

Nucleic Acids Res., 2010
The National Institute of Agrobiological Sciences (NIAS) is implementing the NIAS Genebank Project for conservation and promotion of agrobiological genetic resources to contribute to the development and utilization of agriculture and agricultural ...
Masaru Takeya, Fukuhiro Yamasaki, S. Uzuhashi, T. Aoki, H. Sawada, T. Nagai, K. Tomioka, N. Tomooka, Toyozo Sato, M. Kawase   +9 more
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

. = Banques de données de mutations: enjeux et perspectives pour les maladies génétiques orphelines.

, 2010
Genetic mutation databases: stakes and perspectives for orphan genetic diseasesNew technologies, which constantly become available for mutation detection and gene analysis, have contributed to an exponential rate of discovery of disease genes and ...
Thèze, C, Paulet, D, Collod-Béroud, G, Baux, D, Claustres, M, Roux, A-F, Hamroun, D, Desmet, F-O, Girardet, A, Bareil, C, des Georges, M, Béroud, C, Humbertclaude, V, Tuffery-Giraud, S, Khau Van Kien, P   +14 more
core   +1 more source

Opportunities and Challenges for Genetic Studies of End-Stage Renal Disease in Canada

Canadian Journal of Kidney Health and Disease, 2018
Purpose of review: Genetic testing can improve diagnostic precision in some patients with end-stage renal disease (ESRD) providing the potential for targeted therapy and improved patient outcomes.
Vinusha Kalatharan, Mathieu Lemaire, Matthew B. Lanktree   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Molecular marker databases

, 2014
The detection and analysis of genetic variation plays an important role in plant breeding and this role is increasing with the continued development of genome sequencing technologies.
Lorenc, Michal Tadeusz, Kaitao Lai, Lai, Kaitao (R18244), Michał Tadeusz Lorenc, Lorenc, Michal T., Edwards, David, David Edwards, Lai, Kaitao   +7 more
core   +1 more source